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KMID : 1130620210170020229
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Journal of Clinical Neurology
2021 Volume.17 No. 2 p.229 ~ p.235
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Smoking History and Clinical Features of Cluster Headache: Results from the Korean Cluster Headache Registry
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Chung Pil-Wook
Kim Byung-Su
Park Jeong-Wook
Sohn Jong-Hee
Lee Mi-Ji
Kim Byung-Kun
Chu Min-Kyung
Ahn Jin-Young
Choi Yun-Ju
Song Tae-Jin
Bae Dae-Woong
Kim Dae-Young
Kim Jae-Moon
Kim Soo-Kyoung
Park Kwang-Yeol
Chung Jae-Myun
Moon Heui-Soo
Oh Kyung-Mi
Chung Chin-Sang
Cho Soo-Jin
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Abstract
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Background and Purpose: Epidemiologic data suggest that cluster headache (CH) is significantly associated with cigarette smoking. The aim of this study was to determine differences in features between patients with a smoking history and those who are never-smokers, using data from a prospective multicenter registry.
Methods: Data used in this study were obtained from the Korean Cluster Headache Registry that collected data from consecutive patients diagnosed with CH. We compared clinical and demographic features between ever-smokers (current or former smokers) and never-smokers.
Results: This study enrolled 250 patients who were diagnosed with CH, of which 152 (60.8%) were ever-smokers and 98 (39.2%) were never-smokers. The age at CH onset was significantly lower in the never-smoker group than in the ever-smoker group [27.1±12.9 years vs. 30.6±10.9 years (mean±standard deviation), p=0.024]. Seasonal rhythmicity (58.1% vs. 44.7%, p=0.038) and triptan responsiveness (100% vs. 85.1%, p=0.001) were higher in never-smokers, while other clinical features such as pain severity, duration, attack frequency, and associated autonomic symptoms did not differ significantly between the groups. The male-to-female ratio was markedly higher in ever-smokers (29.4:1) than in never-smokers (1.7:1).
Conclusions: Most of the clinical features did not differ significantly between patients with a smoking history and never-smokers. However, the age at CH onset, sex ratio, and seasonal rhythmicity were significantly associated with smoking history.
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KEYWORD
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cluster headache, smoking, sex differences
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